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. Author manuscript; available in PMC: 2020 Jun 10.
Published in final edited form as: J Control Release. 2019 Apr 4;303:289–301. doi: 10.1016/j.jconrel.2019.03.030

Figure 5:

Figure 5:

HPLC analysis of dopamine (DA) and its key metabolites (HVA and DOPAC) in the ventral midbrain and the striatum. The results are reported as ratios of ipsilateral over contralateral levels to capture the unilateral effect of our intervention. A twofold increase in the levels of DA can be observed in the midbrain of the hemispheres treated once with ultrasound and NTN compared to the rest of the groups (one way ANOVA, F[3, 13] = 7.055; P=0.0047). This trend is preserved for the metabolites but lacks significance. This lateralized increased dopamine level was not observed in the striatum despite the small increase in the metabolites observed in the FUS/NTN group compared to the MPTP only group.