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Study design (A) and schedule of visits and assessments (B). Dose escalation to 6 g CSL112 was recommended following Data Safety and Monitoring Board review of data for the 2 g CSL112 dose. DSMB, Data and Safety Monitoring Board; Mod RI, moderate renal impairment; NRF, normal renal function; PD, pharmacodynamics; PK, pharmacokinetics.
