Table 2.

Plasma Pharmacokinetic Parameters (Baseline Corrected) for Apolipoprotein A‐I (apoA‐I), Phosphatidylcholine (PC), and Sucrose (Unadjusted) Following Infusion of CSL112

	CSL112 2 g		CSL112 6 g
	Normal Renal Function	Moderate RI	Normal Renal Function	Moderate RI
ApoA‐I
Cmax, mg/dL	42.7 ± 3.50	44.0 ± 12.0	162 ± 13.0	152 ± 24.3
Tmax, h	2.05 (2.03‐2.10)	2.00 (2.00‐8.00)	2.01 (2.00‐2.22)	2.00 (2.00‐4.00)
AUC0‐last, mg·h/dL	2570 ± 1620	2030 ± 862	7670 ± 1900	9170 ± 2910
AUC0‐72, mg·h/dL	1550 ± 585	1510 ± 219	5140 ± 847	5890 ± 1560
t1/2, h	ND	36.8 ± 23.8	97.8 ± 59.3	91.8 ± 28.0
PC
Cmax, mg/dL	68.5 ± 6.60	67.2 ± 15.7	228 ± 14.3	208 ± 28.9
Tmax, h	2.05 (2.03‐2.10)	2.00 (2.00‐8.00)	2.01 (2.00‐2.22)	2.00 (2.00‐4.00)
AUC0‐last, mg·h/dL	2230 ± 1610	1620 ± 1530	5250 ± 1870	6400 ± 2950
AUC0‐72, mg·h/dL	745 ± 107	749 ± 164	2320 ± 233	2420 ± 539
t1/2, h	ND	28.6 ± 28.9	ND	ND
Sucrose
Cmax, mg/dL	10.0 ± 1.0	12.9 ± 1.7	35.6 ± 2.6	35.7 ± 14.3
Tmax, h	2.05 (2.03‐2.10)	2.05 (2.00‐4.00)	2.01 (2.00‐2.22)	2.00 (2.00‐8.00)
AUC0‐last, mg·h/dL	29.3 ± 13.3	76.5 ± 41.1	116 ± 21.2	199 ± 157

Values are the arithmetic mean ± standard deviation or median (range).

AUC, area under the curve; 0‐last, time zero to the last quantifiable point (following baseline correction); C_max, maximum concentration in plasma; ND, not determined; RI, renal impairment; T_max, time to maximal plasma concentration; t_1/2, terminal half‐life