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. 2019 Jul 2;25:4892–4900. doi: 10.12659/MSM.915858

Figure 5.

Figure 5

miR-149 inhibits LPS-induced ECM degradation and inflammation response by targeting MyD88. (A) The mRNA expression of MyD88 in LPS-stimulated NP cells transfected with miR-149 and/or MyD88. * P<0.05. (B) The protein expression of MyD88 in LPS-stimulated NP cells transfected with miR-149 and/or MyD88. * P<0.05. (C) MyD88 transfection suppressed the levels of aggrecan and collagen II promoted by miR-149 in LPS-treated NP cells. ** P<0.01. (D) MyD88 transfection restored the levels of MMP3 and ADAMTS4 repressed by miR-149 in LPS-treated NP cells. ** P<0.01. (E) MyD88 transfection rescued the levels of TNFα, IL-1, and IL-6 inhibited by miR-149 in LPS-treated NP cells. ** P<0.01.