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. 2019 Jul 3;10:731. doi: 10.3389/fneur.2019.00731

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Copyright © 2019 Kalinichenko, Mühle, Eulenburg, Praetner, Reichel, Gulbins, Kornhuber and Müller.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Alcohol preference (A) and alcohol consumption (B) on the model of two-bottle free-choice drinking is enhanced in homozygous mice with acid sphingomyelinase deficiency (ASM−/−) compared to wild type animals (wt). The levels of water intake (C) and total fluid intake (D) do not significantly differ between ASM−/− and wt mice. Stress (E) overwrites the differences in the drinking pattern of these animals. The hatched box indicates the time of stress exposure. The error bars show the mean ± SEM (*p < 0.05 vs. wt animals; ###p < 0.001, ##p < 0.01 vs. baseline, BS).