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. 2019 Jul 3;10:731. doi: 10.3389/fneur.2019.00731

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Copyright © 2019 Kalinichenko, Mühle, Eulenburg, Praetner, Reichel, Gulbins, Kornhuber and Müller.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Sucrose (A) and quinine (B) preference is lower in mice with acid sphingomyelinase deficiency (KO) compared to wt littermates. The duration (D), but not the latency (C) of loss of righting reflex is significantly higher in mice with acid sphingomyelinase deficiency both at day 1 and 8 of alcohol treatment. Blood alcohol concentration (E) does not significantly differ between mice with acid sphingomyelinase deficiency and wt mice. The error bars show the mean ± SEM (*p < 0.05 vs. wt animals).