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The activity of Asm (A) is significantly lower in the dorsal hippocampus of mice with acid sphingomyelinase deficiency (KO) exposed and not exposed to alcohol treatment on the model of two-bottle free-choice drinking. No significant differences in the activities of neutral sphingomyelinase (B), acid ceramidase (C), and neutral ceramidase (D) are observed under these conditions. The error bars show the mean ± SEM (***p < 0.001 vs. wt animals).
