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. 2019 Jul 3;13:642. doi: 10.3389/fnins.2019.00642

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Copyright © 2019 Yang, Zhuang, Bird, Sreenivasan, Mishra, Banks, Cordes and the Alzheimer's Disease Neuroimaging Initiative.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Flow chart of sPCA+CCA. sPCA was carried out reduce data dimensions and to suppress irrelevant features. Then, CCA was carried out for fusion analysis to obtain modulation profiles and associated components. In the flow chart ${\hat{X}}_{r} = U_{r} D_{r} V_{r}^{T} w i t h r = 1, 2$ , is the data matrix of the two modalities obtained from sPCA.