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. 2019 Jul 3;13:642. doi: 10.3389/fnins.2019.00642

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Copyright © 2019 Yang, Zhuang, Bird, Sreenivasan, Mishra, Banks, Cordes and the Alzheimer's Disease Neuroimaging Initiative.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Correlation between the most significant modulation profiles in ECM and VBM modalities with SUVR. The significance p-values for ECM (p_ECM) and VBM data (p_VBM) in sPCA+CCA, PCA+CCA, parallel ICA and sCCA are also shown. The SUVR measures the content of ß-amyloid using PET scanning. The ECM modulation profile of the disease-related pattern measures the strength of functional connectivity. A more negative value indicates lower functional connectivity. The VBM modulation profile of the disease-related pattern relates to the amount of atrophy. More atrophy is present for negative values of the VBM modulation profile. Note that sPCA+CCA has the most significant negative correlation with SUVR.