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Influence of campesterol on β- and γ-secretase. A, Effect of campesterol on β-secretase activity, gene expression, and protein level of BACE1. B, Influence of campesterol on γ-secretase activity, gene expression of the γ-secretase complex, and PS1 protein level. A, B, Sterol concentration used and analysis of secretase activities, gene expression, and protein level as described for Figure 3. Illustration and statistical significance as described for Figure 2; n ≥ 5.
