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. 2013 Sep 4;33(36):14331–14341. doi: 10.1523/JNEUROSCI.1681-13.2013

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Copyright © 2013 the authors 0270-6474/13/3314331-11$15.00/0

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Figure 3. — LTD of subthalamo-nigral transmission is lost in dopamine-depleted animals. a, Tetanic stimulation-induced (tetanus) LTD of STN-SNr transmission. Normalized eEPSC amplitudes (normalization to the mean amplitude of eEPSCs recorded during baseline acquisition) are plotted against time (n = 25). a–d, Arrow indicates the time of induction (tetanus), and error bars represent SEM. Inset, Traces from a representative experiment illustrating the average eEPSC from 0 to 5 min (1) and 30 to 35 min (2). b, Evolution of the PPR during LTD induction experiments. PPRs are plotted against time. Inset, Traces from a representative experiment illustrating the average eEPSC from 0 to 5 min (1, black) and 30 to 35 min (2, gray). c, LTD induction protocol at STN-SNr synapses from DA-depleted animals (n = 13). The gray line represents the shape of control tetanus-induced LTD from Figure 2a for comparison (control vs 6-OHDA, p < 0.0001; one-way ANOVA with Tukey's post hoc test). Inset, Traces from a representative experiment illustrating the average eEPSC from 0 to 5 min (1) and 30 to 35 min (2). d, Evolution of the PPR during LTD induction experiments performed on slices from DA-depleted animals. PPRs are plotted against time. Insets, Traces from a representative experiment illustrating the average eEPSC from 0 to 5 min (1, black) and 30 to 35 min (2, gray).