Figure 6.

Effects on endogenous mAβ in 12-month-old Tg2576 mice treated with AZ-4217. In the same Tg2576 brain extracts, as hAβ were measured, we also evaluated the effects on endogenous mAβ. Significant reductions of soluble endogenous brain mAβ40 and mAβ42 were observed after 7 d of treatment (A, B). As with hAβ-insoluble endogenous brain mAβ40, hAβ42 only displayed significant effects after 28 d of treatment (C, D). Data are presented as mean values ± SEM (*p < 0.05; **p < 0.01, ***p < 0.001, compared with vehicle). The mean levels (pg/mg tissue ± SEM, n = 77) in the vehicle-treated groups were 8 ± 0.5 (soluble mAβ40), 8 ± 0.4 (soluble mAβ42), 53 ± 3 (insoluble mAβ40), and 88 ± 5 (insoluble mAβ42).