Table 2.
Mean ± SEM number of labeled varicosities in CN per labeled mossy fiber in the MCP
| Untrained BDA in lateral BPN animals (n = 8) | Pseudoconditioned BDA in lateral BPN animals (n = 5) | Conditioned BDA in medial BPN animals (n = 5) | Conditioned BDA in lateral BPN animals (n = 12) | Varicosities/MCP fiber (ANOVA, p value) | Tukey–Kramer post hoc p value |
||||
|---|---|---|---|---|---|---|---|---|---|
| Cl-Un | Cl-Ps | Cl-Cm | Cm-Un Ps-Un Ps-Cm | ||||||
| Bilateral | |||||||||
| CN | 4.46 ± 1.32 | 7.77 ± 2.13 | 1.65 ± 0.20 | 19.10 ± 3.91 | 0.001 | 0.012 | 0.015 | 0.010 | n.s. |
| Lateral CN | 2.21 ± 0.49 | 3.30 ± 0.86 | 1.07 ± 0.15 | 8.44 ± 1.50 | 0.001 | 0.008 | 0.084 | 0.007 | n.s. |
| Interposed CN | 2.11 ± 0.93 | 3.64 ± 1.10 | 0.55 ± 0.21 | 8.57 ± 1.54 | 0.001 | 0.012 | 0.150 | 0.007 | n.s. |
| PIN | 1.24 ± 0.50 | 3.27 ± 0.98 | 0.32 ± 0.21 | 4.52 ± 0.94 | 0.007 | 0.050 | 0.814 | 0.027 | n.s. |
| AIN | 0.87 ± 0.49 | 0.36 ± 0.23 | 0.23 ± 0.13 | 4.05 ± 0.82 | 0.001 | 0.017 | 0.018 | 0.013 | n.s. |
| DLH | 0.16 ± 0.08 | 0.07 ± 0.04 | 0.14 ± 0.08 | 1.67 ± 0.34 | 0.000 | 0.003 | 0.007 | 0.011 | n.s. |
| Medial CN | 0.14 ± 0.08 | 0.83 ± 0.67 | 0.00 ± 0.00 | 2.10 ± 0.84 | 0.124 | 0.232 | 0.713 | 0.302 | n.s. |
| Left CN | |||||||||
| CN | 3.67 ± 1.39 | 6.06 ± 1.50 | 1.28 ± 0.21 | 7.59 ± 0.97 | 0.006 | 0.065 | 0.818 | 0.006 | n.s. |
| Lateral CN | 1.64 ± 0.48 | 2.62 ± 0.60 | 0.94 ± 0.16 | 3.12 ± 0.49 | 0.029 | 0.131 | 0.911 | 0.037 | n.s. |
| Interposed CN | 1.89 ± 0.95 | 2.63 ± 0.81 | 0.31 ± 0.18 | 3.32 ± 0.38 | 0.029 | 0.323 | 0.887 | 0.020 | n.s. |
| PIN | 1.11 ± 0.50 | 2.29 ± 0.85 | 0.16 ± 0.12 | 1.95 ± 0.48 | 0.098 | 0.691 | 0.972 | 0.141 | n.s. |
| AIN | 0.78 ± 0.49 | 0.33 ± 0.24 | 0.15 ± 0.08 | 1.37 ± 0.23 | 0.062 | 0.571 | 0.176 | 0.087 | n.s. |
| DLH | 0.11 ± 0.07 | 0.06 ± 0.04 | 0.10 ± 0.05 | 0.66 ± 0.15 | 0.003 | 0.014 | 0.021 | 0.034 | n.s. |
| Medial CN | 0.14 ± 0.08 | 0.82 ± 0.67 | 0.00 ± 0.00 | 1.15 ± 0.49 | 0.220 | 0.307 | 0.959 | 0.330 | n.s. |
| Right CN | |||||||||
| CN | 0.79 ± 0.25 | 1.71 ± 0.72 | 0.37 ± 0.09 | 11.51 ± 3.06 | 0.004 | 0.011 | 0.060 | 0.027 | n.s. |
| Lateral CN | 0.57 ± 0.22 | 0.68 ± 0.26 | 0.14 ± 0.09 | 5.32 ± 1.40 | 0.004 | 0.015 | 0.051 | 0.025 | n.s. |
| Interposed CN | 0.22 ± 0.08 | 1.01 ± 0.55 | 0.23 ± 0.10 | 5.25 ± 1.35 | 0.004 | 0.007 | 0.069 | 0.024 | n.s. |
| PIN | 0.13 ± 0.07 | 0.98 ± 0.54 | 0.16 ± 0.10 | 2.57 ± 0.75 | 0.018 | 0.026 | 0.342 | 0.070 | n.s. |
| AIN | 0.09 ± 0.05 | 0.03 ± 0.02 | 0.08 ± 0.06 | 2.68 ± 0.66 | 0.001 | 0.004 | 0.013 | 0.014 | n.s. |
| DLH | 0.05 ± 0.04 | 0.01 ± 0.01 | 0.04 ± 0.04 | 1.01 ± 0.23 | 0.000 | 0.002 | 0.006 | 0.008 | n.s. |
| Medial CN | 0.00 ± 0.00 | 0.01 ± 0.01 | 0.00 ± 0.00 | 0.94 ± 0.37 | 0.056 | 0.100 | 0.204 | 0.191 | n.s. |
Mean ± SEM number of labeled varicosities per fiber mossy fiber in the MCP specified for different regions of the cerebellar nuclei (CN). No significant differences were found between the untrained group, the pseudoconditioned group, and the conditioned group with BDA injected in non-auditory medial parts of the right BPN. Conditioned animals with BDA injected in lateral auditory parts of the right BPN instead show a significant bilateral increase of varicosities per labeled mossy fiber in the MCP. Compared with the three control groups, this increase was most robust in the DLH region. Cl, Conditioned with BDA injection in lateral right BPN, Cm, conditioned with BDA injection in medial right BPN; Ps, pseudoconditioned with BDA injected in lateral right BPN; Un, untrained with BDA injected in lateral right BPN.