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. 2013 Nov 6;33(45):17874–17883. doi: 10.1523/JNEUROSCI.2278-13.2013

Figure 3.

Figure 3.

Puberty onset in GABA- and glutamate-specific LEPR knock-out animals. A, In GABA-specific LEPR knock-out animals (gray bars; n = 7–10), vaginal opening, first estrus, and male puberty onset were all significantly delayed compared with their control littermates (black bars; n = 7–10). B, Vaginal opening, first estrus, and male puberty onset all occurred at the same time in glutamate-specific knock-out animals (white bars; n = 6–9) compared with their control littermates (black bars; n = 8–9). C, Survival profiles showing puberty onset of female GABA-specific LEPR knock-out (gray lines) and control animals (black lines). The percentage of mice showing vaginal opening (intermittent lines) and first estrus (continuous lines) is plotted for each time point. D, Puberty onset (date of first successful mating) profiles of male GABA-specific knock-outs (gray line) and controls (black line) over time is plotted. VO, Vaginal opening. *p < 0.05. **p < 0.01. ***p < 0.001.