Table 1.

Regional FDOPA kinetic results according to the reversible inlet–outlet model

Region	Parameter	Mean	SD	Skewness
				Statistic	SE
Midbrain	K	0.0076	0.0030	1.43	0.50
	kloss	0.0058	0.0062	−2.79
	Vd	1.56	0.59	−0.19
NC	K	0.0184	0.0039	0.12
	kloss	0.0034	0.0011	0.29
	Vd	6.21	1.76	0.55
Putamen	K	0.0213	0.0044	0.52
	kloss	0.0042	0.0012	1.37
	Vd	5.56	1.39	0.01
Thalamus	K	0.0098	0.0034	0.59
	kloss	0.0139	0.0046	−2.56
	Vd	1.07	0.23	0.34

K, intrinsic blood–brain clearance of FDOPA [ml·g⁻¹ · min⁻¹]; k_loss, rate constant for the elimination of [¹⁸F]-fluorodopamine and subsequent metabolites [min⁻¹]; V_d, total distribution volume of FDOPA and its decarboxylated metabolites in brain tissue [ml/g].