Figure 7.

Impaired adaptation of VOR in γ2pepV mice. Effects of γ2pepV on the VOR gain-increase (A–E), the VOR gain-decrease (F–J), and the OKR (K–O) trainings. Representative eye-position traces (A, F, K, averages of 10 cycles) before (gray lines) and after (black lines) each training. Changes in the gain (B, D, G, I) and the phase (C, E, H, J) before and after VOR trainings (n = 5 for each), and changes of the gain (L, N) and the phase (M, O) during the OKR training (n = 7 for each). The gain was increased (B) and the phase was decreased (C) significantly by the gain-increase training in control mice but not in γ2pepV mice. The gain-decrease training and the OKR training changed the gain and phase in the two genotypes (G, H). The gain changes after the gain-increase (D) and the gain-decrease (I) training were different between the genotypes. Data are mean ± SEM. B, C, G, H, *p < 0.05 (significant differences between before and after). **p < 0.01 (significant differences between before and after). D, I, *p < 0.05 (significant difference between the two genotypes). **p < 0.01 (significant difference between the two genotypes).