Table 2.
Activations for motor responses during painful thermal stimulation (pain press vs pain no-press), motor responses during nonpainful thermal stimulation (no-pain press vs no-pain no-press), and the conjunction of motor responses during both painful and nonpainful stimulation (conjunction of painful and nonpainful movement contrasts)a
| Brain region/contrast | Peak coordinates (Talairach) | Maximum t-score | Cluster size (mm3) |
|---|---|---|---|
| Movement: pain press (pain press > pain no-press) | |||
| Midcingulate cortex | 2, 13, 30 | 4.32 | 374 |
| Precentral gyrus | −35, −23, 60 | 4.09 | 751 |
| Postcentral gyrus | −31, −32, 63 | 4.32 | 374 |
| Supramarginal gyrus | −52, −32, 39 | 4.79 | 760 |
| Anterior insula | 32, 13, 12 | 4.48 | 202 |
| Cerebellum (vermis VI) | −1, −65, −12 | 6.73 | 2431 |
| Cerebellum (lobule V/VI) | 14, −62, −27 | 5.54 | 3146 |
| Cerebellum (lobule VI) | −4, −68, −14 | 5.81 | 2182 |
| Thalamus | −10, −2, 12 | 6.96 | 2563 |
| Thalamus | 5, −17, 12 | 8.22 | 1508 |
| Striatum (caudate) | −25, −14, 3 | 7.07 | 5576 |
| Striatum (caudate) | 23, 4, 3 | 5.49 | 1600 |
| Red nucleus/substantia nigra | −4, 17, −9 | 6.22 | 1312 |
| Movement: no-pain press (no-pain press > no-pain no-press) | |||
| Midcingulate cortex | −1, 7, 39 | 5.77 | 1058 |
| Postcentral gyrus | −49, −29, 45 | 5.64 | 3907 |
| Postcentral gyrus | −37, −29, 57 | 4.65 | 1127 |
| Midinsula | −43, −2, 6 | 10.14 | 2004 |
| Cerebellum (vermis) | 3, −46, −18 | 8.09 | 7370 |
| Cerebellum (lobule V/VI) | 14, −50, −24 | 8.09 | 4409 |
| Thalamus | −1, −20, 6 | 5.93 | 929 |
| Striatum (caudate-body) | −16, −11, 21 | 4.69 | 333 |
| Striatum (caudate-body) | 8, 19, 15 | 5.79 | 533 |
| Striatum (putamen) | −28, −5, 0 | 3.68 | 99 |
| Conjunction | |||
| Midcingulate cortex | −1, 10, 36 | 3.58 | 94 |
| Precentral gyrus | −37, 20, 58 | 4.07 | 141 |
| Postcentral gyrus | −37, −35, 57 | 4.15 | 174 |
| Frontal operculum | −46, 7, 3 | 3.96 | 168 |
| Cerebellum (vermis) | −1, −56, −21 | 5.66 | 1543 |
| Cerebellum (lobule V/VI) | 17, −50, −24 | 4.88 | 2485 |
| Thalamus | −10, −20, 9 | 4.26 | 366 |
| Striatum (caudate-body) | −16, −20, 18 | 4.11 | 211 |
| Red nucleus/substantia nigra | −4, −23, −9 | 4.16 | 15 |
aThermal stimulation was delivered to the left hand, and responses were made with the right. All contrasts thresholded at a whole-brain familywise error–corrected level of p < 0.05.