Figure 5.

The stochastic effect of Ca²⁺-activated K⁺ channels is large compared with the stochastic effect of voltage-gated Ca²⁺ channels. A–D, Voltage traces for 50 iterations are plotted using a hybrid model (with compartment length of 10 μm) with (A) stochastic Ca_v2.1 channels, (B) stochastic Ca_v3.1 channels, (C) stochastic mslo channels, and (D) stochastic SK2 channels. All other mechanisms, except the mentioned stochastic channels, are simulated deterministically. A–D, Insets, Aligned traces at −30 mV to highlight the variability of spike features in each model over multiple runs.