Figure 2.

Blockade of 5-HT2AR in mPFC impairs recency discrimination during retrieval. A, Training and testing scheme. Animals were exposed to an arena containing two identical copies of an object and an hour later re-exposed to the same arena containing two identical copies of a different object. Three hours later rats were exposed to the same context containing one copy of each object. B, Fifteen minutes before the test session rats were infused with 300 ng/μl MDL 11,939 or vehicle (Veh) into the mPFC. Discrimination index was calculated as the time spent exploring the older object minus the time spent exploring the recent object over the total exploration time during the test session; n = 7 per group, *p < 0.05, Student's t test.