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. 2013 Jun 26;33(26):10828–10839. doi: 10.1523/JNEUROSCI.1021-13.2013

Figure 4.

Figure 4.

Ih-dependent depolarizing sag and rebound are upregulated in proestrous mice. A, Example traces illustrating the depolarizing sag and rebound seen in OVX, diestrous, and proestrous RP3V kisspeptin neurons in response to hyperpolarizing current injections in the presence of a cocktail of synaptic and ion channel blockers (see Results). Arrowheads indicate the depolarizing sag. B, Histograms summarizing the amplitude of the depolarizing sag and rebound in OVX (n = 15 neurons, 4 mice), diestrus (Di; n = 15 neurons, 4 mice), and proestrus (Pro; n = 13 neurons, 4 mice). C, D, In proestrous RP3V kisspeptin neurons, both sag and rebound were inhibited by 10 μm ZD7288 (n = 6 neurons, 4 mice). *p < 0.05, **p < 0.01, ***p < 0.001.