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. 2013 Jun 26;33(26):10828–10839. doi: 10.1523/JNEUROSCI.1021-13.2013

Figure 7.

Figure 7.

Ih differentially alters basic membrane properties in diestrous and proestrous RP3V kisspeptin neurons. A, Membrane hyperpolarization in diestrous and proestrous RP3V kisspeptin neurons in response to a 0.5 s step current injection in the absence (black trace) and in the presence (gray trace) of 10 μm ZD7288. Current injection was adjusted in the proestrous neuron to account for the ZD7288 increase in input resistance and reach a similar peak hyperpolarization (control: −50 pA; ZD7288: −30 pA). The same traces at a higher time resolution are shown below, illustrating the larger ZD7288-induced slowing of the membrane time constant in proestrous RP3V kisspeptin neurons. B, Summary graph of the effect of ZD7288 on input resistance in diestrous (n = 11 neurons, 4 mice) and proestrous (n = 11 neurons, 5 mice) kisspeptin neurons. C, Summary graph of the effect of ZD7288 on the membrane time constant of RP3V kisspeptin neurons in diestrus (n = 10 neurons, 4 mice) and proestrus (n = 11 neurons, 5 mice). ns, Not significant, *p < 0.05, ***p < 0.001.