Table 1.
Synopsis of C-fibers: characteristics of fiber populations
| Mouse strain | Number of mice | Number of fibers | CV (m/s) | von Frey threshold (mN) | Fiber subtypes |
|||
|---|---|---|---|---|---|---|---|---|
| CM | CMC | CMCH | CMH | |||||
| C57BL/6 | 13 | 24 | 0.38 ± 0.10 (0.25–0.63) | 11.4 (1.4–64) | 5 | 5 | 9 | 5 |
| C57BL/6 and TRPV1+/+ | 21 | 38 | 0.42 ± 0.14 (0.23–0.90) | 32 (4–128) | 18 | 5 | 6 | 9 |
| TRPV1−/− | 13 | 28 | 0.42 ± 0.13 (0.29–0.95) | 16 (1–45.3) | 7 | 5 | 3 | 13 |
| TRPM8+/+ (N5F1) | 13 | 32 | 0.50 ± 0.12 (0.34–0.87) | 5.7 (1.4–22.6) | 4 | 7 | 9 | 12 |
| TRPM8−/− (N5F1, N4F3) | 6 (N5F1) 4 (N4F3) | 32 | 0.48 ± 0.18 (0.19–1.19) | 16 (1.4–128) | 6 | 0 | 8 | 18 |
| C57BL/6 | 7 | 14 | 0.52 ± 0.15 (0.36–0.9) | 8 (1–32) | 3 | 6 | 2 | 3 |
| TRPM8−/− (N5F6) | 6 | 22 | 0.46 ± 0.25 (1.22–0.28) | 5.7 (2.8–32) | 7 | 1 | 7 | 7 |
| TRPM8+/+ (N5F5) | 1 | 2 | 0.3 ± 0.1 (0.23–0.37) | 9.7 (8–11.4) | 0 | 2 | 0 | 0 |
| C57BL/6 | 7 | 8 | 0.3 ± 0.1 (0.22–0.49) | 4 (1–32) | 0 | 8 | 0 | 0 |
Values are given as number, mean ± SE (range), or median (range). The table lists number of mice per strain, conduction velocity (CV), von Frey threshold (mN), and mechanosensitive C-fibre subtypes. CM, C-Mechano; CMC, C-Mechano-Cold; CMCH, C-Mechano-Cold-Heat; CMH, C-Mechano-Heat.