Table 2.
Synopsis of C-fibers: treatment with cooling compounds menthol and camphor or M-channel modulators XE991 and retigabine
| Compound | Mouse strain | All treated (cold-sensitive) | All sensitized | Sensitized cold-sensitive | Sensitized cold-insensitive |
|---|---|---|---|---|---|
| Menthol | C57BL/6 | 24 (14) | 8 (33%) | 4 (29%) | 4 (40%) |
| Camphor | C57BL/6 and TRPV1+/+ | 38 (11) | 11 (29%) | 4 (40%) | 7 (25%) |
| TRPV1−/− | 28 (8) | 9 (32%) | 3 (38%) | 6 (30%) | |
| TRPM8+/+ | 32 (16) | 6 (19%) | 4 (25%) | 2 (13%) | |
| TRPM8−/− | 32 (8) | 2 (6%) | 1 (13%) | 1 (4%) | |
| XE991 | C57BL/6 | 14 (10) | 7 (47%) | 7 (64%) | — |
| TRPM8−/− | 22 (8) | — | — | — | |
| TRPM8+/+ | 2 (2) | 2 | 2 | — | |
| Menthol ± retigabine/XE991 | C57BL/6 | 8 (8) | 8 | 8 | — |
For details see text and materials and methods.