Skip to main content
. 2013 Oct 16;33(42):16729–16740. doi: 10.1523/JNEUROSCI.5523-12.2013

Figure 2.

Figure 2.

Blockage of erg currents increases Purkinje cell excitability. A, Repetitive activity elicited with a 100 pA depolarizing current of 500 ms duration before (Aa) and after (Ab) application of 5 μm E-4031. B, Phase plane plot used to determine the threshold potential. The head of the continuous arrows indicates the threshold potential of the first action potential. The head of the interrupted arrow indicates the mean of the threshold potential of the remaining action potentials (Ba). After application of 5 μm E-4031, the threshold potential of the first action potential as well as of the remaining action potentials attained more negative membrane potentials (Bb). C, IFF measured in 12 neurons before (gray points) and during (black points) application of E-4031 (means ± SEM). The first 11 action potentials were evaluated. D, Mean firing frequencies of repetitive activity elicited with 500 ms current pulses of increasing amplitude (**p < 0.01, ***p < 0.001; n = 24).