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Impaired central leptin signaling in LMO4KO mice is associated with elevated PTP1B activity. A, Immunoblot analysis of leptin signaling in hypothalamic wedges. To measure oxi-PTP1B with a pan-oxi-PTP antibody, PTP1B was immunoprecipitated (IP) with rabbit anti-PTP1B antibody and then the immunoblot (IB) probed with mouse anti-oxi-PTP antibody. B, PTP1B activity in hypothalamic wedges. n = 6 per time point. *p < 0.05 compared with baseline; **p < 0.05 compared with the previous value.
