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. 2013 Jul 31;33(31):12647–12655. doi: 10.1523/JNEUROSCI.0746-13.2013

Figure 7.

Figure 7.

The PTP1B inhibitor trodusquemine (Trodu) restores leptin-dependent signaling and regulation of circulating insulin levels in LMO4KO mice. A, Immunoblot analysis of the response to leptin (30 min) with or without pretreatment with trodusquemine (10 μm, 30 min). Ctl, Control. B, Hypothalamic PTP1B activity in response to trodusquemine with and without leptin. C, Serum insulin in response to leptin with and without trodusquemine. D, The effect of intracerebroventricular administration of trodusquemine and/or leptin on body weight. B–D, n = 5–8 mice per group, aged 2 months. *p < 0.05 compared with WT saline; #p < 0.05 compared with LMO4KO saline; $p < 0.05, not significant (NS).