Figure 9.

Biophysical simulation of GABA effects on L-type VSCC- and NMDAR-dependent calcium influxes. A, B, Distributions of spine NMDAR-dependent (A) and L-type VSCC-dependent (B) calcium levels along the dendrites in simulated neurons during STDP protocols (n = 15). Results are mean values of the MSN model with 15 sets of random GABA inputs, which are the same as in next panels. Insets: Simulated calcium sample traces. Baselines aligned here. C, D, Ratio between NMDAR and L-type VSCC calcium in simulated neurons (n = 15) during post-pre (C) or pre-post (D) STDP protocols. Arrows indicate the effect on the balance between NMDA- and L-type calcium with successively increasing GABA inputs.