Figure 6.

Absence of axon and synaptic reorganization in the surrounding neuropil. A, Individual axons were lesioned, often as close to few μm from nearby axons (inset) and the surrounding neuropil analyzed for up to 11 d postlesion. Pale gray arrows indicate intact axon before lesion, red arrowheads indicate the axonal stump, and blue arrowheads indicate previous trajectory of degenerated axonal segment. B, 10 and 30 μm analysis diameter bins (red circles) were created surrounding the lesion site. There was no significant difference in either total axonal length (C), data normalized to prelesion length, within 10, 30, and 100 μm or synaptic density (D), data normalized to prelesion density, detected in the surrounding circuitry after the lesion. n.s., Nonsignificant. Scale bars: A, 20 μm; B, 30 μm.