Table 2.
Statistical analysis of the performance of Stop-CB1, WT, and CB1-RS mice in fear extinction
| Repeated-measures ANOVA | Factor | F | p | Post hoc G | p |
|---|---|---|---|---|---|
| For 20 s time bins | |||||
| d1 | G × T | F(9.20,124.22) = 1.40 | 0.193 | Stop-CB1 vs WT | 0.033 |
| T | F(4.60,124.22) = 28.19 | <0.001 | Stop-CB1 vs CB1-RS | 0.005 | |
| G | F(2,27) = 6.70 | 0.004 | WT vs CB1-RS | 1.000 | |
| d2 | G × T | F(11.42,154.15) = 1.76 | 0.062 | Stop-CB1 vs WT | 0.025 |
| T | F(5.71,154.15) = 16.55 | <0.001 | Stop-CB1 vs CB1-RS | 0.008 | |
| G | F(2,27) = 6.41 | 0.005 | WT vs CB1-RS | 1.000 | |
| d3 | G × T | F(9.94,134.24) = 0.88 | 0.557 | Stop-CB1 vs WT | 0.008 |
| T | F(4.97,134.24) = 16.02 | <0.001 | Stop-CB1 vs CB1-RS | 0.137 | |
| G | F(2,27) = 5.56 | 0.010 | WT vs CB1-RS | 0.723 | |
| d10 | G × T | F(8.39,113.27) = 0.76 | 0.642 | Stop-CB1 vs WT | <0.001 |
| T | F(4.20,113.27) = 7.71 | <0.001 | Stop-CB1 vs CB1-RS | 0.027 | |
| G | F(2,27) = 12.47 | <0.001 | WT vs CB1-RS | 0.120 | |
| For days | |||||
| Tone minus Baseline | G × T | F(6,81) = 1.41 | 0.220 | Stop-CB1 vs WT | <0.001 |
| T | F(3,81) = 36.02 | <0.001 | Stop-CB1 vs CB1-RS | 0.003 | |
| G | F(2,27) = 10.62 | <0.001 | WT vs CB1-RS | 1.000 | |
| Initial 20 s minus Baseline | G × T | F(6,81) = 2.17 | 0.054 | Stop-CB1 vs WT | nd |
| T | F(3,81) = 23.83 | <0.001 | Stop-CB1 vs CB1-RS | nd | |
| G | F(2,27) = 2.02 | 0.152 | WT vs CB1-RS | nd | |
| Baseline | G × T | F(6,81) = 0.39 | 0.885 | Stop-CB1 vs WT | nd |
| T | F(3,81) = 47.60 | <0.001 | Stop-CB1 vs CB1-RS | nd | |
| G | F(2,27) = 0.02 | 0.982 | WT vs CB1-RS | nd | |
| After tone | G × T | F(6,81) = 0.30 | 0.937 | Stop-CB1 vs WT | 0.004 |
| T | F(3,81) = 8.65 | <0.001 | Stop-CB1 vs CB1-RS | 0.181 | |
| G | F(2,27) = 6.52 | 0.005 | WT vs CB1-RS | 0.336 |
G, genotype; T, time; d, day; nd, not determined.