Figure 2.
NPY increases the CF with glutamate and GABA synaptic transmission blocked. A, Bath application of kynurenic acid (1 mm) and picrotoxin (100 μm) to block glutamate- and GABA-gated ionotropic receptors, respectively, and the selective GABAB receptor antagonist CGP 46381 (20 μm; Antagonists, black trace) did not alter the CF compared to control (data not shown). With these antagonists present, 1 μm NPY (dotted trace) still inhibits the ADP recorded at the soma at the CF. B, NPY significantly increases the average CF in the presence of these antagonists (n = 7). These actions reverse upon washout of NPY (data not shown) *p < 0.05 (paired t test). Error bars indicate ±SEM.