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. 2013 Jul 10;33(28):11715–11723. doi: 10.1523/JNEUROSCI.3541-12.2013

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Copyright © 2013 the authors 0270-6474/13/3311715-09$15.00/0

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Figure 4. — Early IGF-1 blockade prevents the effects of early postnatal massage and EE on adult anxiety-like behavior. A, Experimental protocols. B, C, Mean percentage of time spent in the open arms (B) and mean percentage of entries in the open arms (C) at P60 for MSG and EE rats treated with JB1, for MSG and EE rats treated with Veh, and for CNT rats. CNT or JB1-treated rats differ from Veh-treated EE or MSG rats (asterisks, p < 0.001; §p = 0.01); CNT and JB1-treated groups do not differ (one-way ANOVA). Vertical bars are SEM. D1, D2, Mean total arm entries (D1) and mean distance moved (D2) for all experimental groups during the test session. No difference was found between groups (one-way ANOVA). Vertical bars are SEM.