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Schematic model showing KIF3C localization and function at the microtubule plus-ends. A, EB3 targets KIF3C to the plus-end of microtubules (MTs) in the growth cone. Here, KIF3C regulates microtubule dynamics and functions as a microtubule-destabilizing factor. B, The microtubule-destabilizing role of KIF3C is necessary to achieve appropriate axonal growth and regeneration after injury (B).
