Figure 11.

Systemic injection of mGlu4 agonist alleviates mechanical hypersensitivity in inflammation. Results are expressed by the time course curves of mean ± SEM of vocalization threshold to paw pressure (expressed in grams) in the left panel and by the area under the curve (AUC, g.min) in the right panel. Rats were treated with vehicle, LSP4–2022 (various doses as indicated in milligrams per kilogram, i.p.), or morphine (6 mg/kg, i.p.) administered 240 min after intraplantar injection of carrageenin (n = 8 animals per group). *p < 0.05 versus vehicle-treated group. **p < 0.01 versus vehicle-treated group. ***p < 0.001 versus vehicle-treated group.