Figure 6.

Inhibition of spinal excitatory neurotransmission by mGlu4 receptor is reinforced in inflammation. Electrophysiological recording of current eEPSCs in lamina II neurons from spinal cord slices of naive or inflamed young mice. Inflammation was induced by administration of CFA solution in hindpaws. Spinal cords were removed and recordings performed 24 h after the injection. A, Sample current traces recorded before and after 5 or 50 μm LSP4–2022 application in naive or CFA-treated mice. B, Histogram of mean ± SEM eEPSC amplitude after application of 5 or 50 μm LSP4–2022 in naive or inflamed mice, expressed as percentage of current amplitude before drug application. *p < 0.05.