Figure 8.

Pharmacological activation of spinal mGlu4 receptors reduces mechanical hypersensitivity induced by inflammation on mice. Time course and area under the curve of mean ± SEM of the number of paw lifts of five stimulations using von Frey filaments corresponding to innocuous (A), intermediate (B), and noxious (C) bending forces (0.07, 0.6, and 1.4 g, respectively) on inflamed C57BL/6 mice treated by various doses of LSP4–2022 (as indicated) 240 min after carrageenan injection (n = 6–8 animals per group). *p < 0.05, vehicle versus treated conditions. **p < 0.01, vehicle versus treated conditions.