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. 2013 Dec 11;33(50):19396–19405. doi: 10.1523/JNEUROSCI.2073-13.2013

Figure 4.

Figure 4.

Inhibition of intracellular calcium stores does not affect SK channel activation. A, AP-evoked change in fluorescence in a spine (left) and dendrite (right) in the presence of cyclopiazonic acid (CPA) to deplete intracellular calcium stores (30 μm; black) and after application of apamin (1 μm) in the presence of CPA (red). B, Average AP-evoked peak ΔF/F in spines before and after the application of apamin in the continued presence of CPA (±SEM; n = 10). C, Average percentage change in AP-evoked fluorescence after the application of apamin in the presence of CPA (±SEM; n = 10). D, Change in fluorescence at the soma in response to a 10 ms local application of 100 μm acetylcholine to the soma in normal ACSF (black) and in the presence of CPA (blue). E, Average change in fluorescence during somatic acetylcholine applications in ACSF and CPA (n = 4). **p < 0.01. ns, Not significant.