Table 1. Variables for Base Case and Sensitivity Analyses.
Variable | Base Case | One-way Sensitivity Analysisa | Probabilistic Sensitivity Analysisb | Source | |||
---|---|---|---|---|---|---|---|
Low Value | High Value | SD | Distribution | ||||
Costs | |||||||
Intermediate costs, 2017 US $c | |||||||
3-mo OCP supply | 38.48 | 0.01 | 5000.00 | 100.68 | Gamma | VA data | |
Dispensing for 3-mo OCP supply | 8.58 | 0.01 | 110.00 | 6.70 | Gamma | VA data | |
Copayment for 3-mo OCP supply | −24.00 | NA | NA | NA | NA | US Department of VA,21 2018 | |
Outcome costs, $ | |||||||
Live birth | |||||||
Prenatal cared | 2968.79 | 100.00 | 15 000.00 | 3789.39 | Gamma | National Partnership for Women and Families27 2013 | |
Intrapartum/delivery care | 7933.67 | 1000.00 | 100 000.00 | 6827.42 | Gamma | VA data | |
Newborn care (7 d) | 6480.85 | 300.00 | 100 000.00 | 6000.00 | Gamma | VA data | |
Miscarriage | 1186.41 | 100.00 | 5000.00 | 1452.71 | Gamma | VA data | |
Abortion | 0 | NA | NA | NA | NA | US Department of VA28 | |
Probabilities | |||||||
Choose 12-mo supply | 0.50 | 0 | 1.00 | 0.20 | Beta | Assumption | |
Have copayments for OCPs | 0.35 | 0 | 1.00 | 0.10 | Beta | VA data | |
OCP use probabilities | |||||||
Discontinue OCP use given 3 or 12 mo | 0.35 | 0 | 0.07 | 0.10 | Beta | Borrero et al,152013; assumption | |
≥1 gap in coverage given 3 mo | 0.43 | 0 | 0.70 | 0.15 | Beta | Borrero et al,15 2013 | |
Annual pregnancy probabilitiese | |||||||
Pregnancy given continuous OCP use | 0.09 | 0 | 0.20 | 0.05 | Beta | Trussell,6 2011 | |
Pregnancy given discontinued OCPsf | 0.47 | 0 | 1.00 | 0.15 | Beta | Borrero et al,4 2017; Trussell,6 2011 | |
Pregnancy during OCP coverage gap(s) | 0.85 | 0 | 1.00 | 0.08 | Beta | Trussell,6 2011; assumption | |
Pregnancy outcome probabilities | |||||||
Miscarriage | 0.10 | 0 | 0.40 | 0.07 | Beta | American College of Obstetricians and Gynecologists,29 2018 | |
Abortion | 0.42 | 0 | 0.70 | 0.05 | Beta | Finer and Zolna,26 2016 | |
Live birth | 0.48 | NA | NA | NA | NA | NA | |
Pregnancy paid for by VA | 0.52 | 0 | 1.00 | 0.20 | Beta | Borrero et al,4 2017; assumption | |
Newborn care paid for by VAg | 0.58 | 0 | 1.00 | 0.20 | Beta | VA data | |
Durations | |||||||
OCP use given ≥1 coverage gap, mo | 10 | 3 | 11.75h | 1.00 | Beta | Borrero et al,15 2013 | |
OCP use given discontinuation of OCPs, mo | 8 | 0 | 12.00 | 1.5.0 | Beta | Borrero et al,15 2013 |
Abbreviations: NA, not applicable; OCP, oral contraceptive pill; VA, Veterans Affairs.
Cost ranges for 1-way sensitivity analysis are based on extremes of empirical VA data. All other ranges are based on published literature and are intentionally broad to reflect parameter uncertainty and allow for extreme value analysis.30
Distribution means are equal to the base case. Distributions were chosen based on established best practices.30
Intermediate costs are scaled directly based on the minimum number of 3-month supplies necessary to account for time covered by OCPs or multiplied by 4 for 12-month supplies.
Prenatal care costs are based on mean costs paid by commercial insurers for prenatal care in 2010 ($2641), adjusted to 2017 US dollars.
Based on 1 full year of use and prorated in the model to account for the proportion of time in a given state (covered by OCPs, OCP use gap, or discontinuation of OCP use), and for a time horizon of twelve 28-day periods (336 days) instead of a full calendar year.
The base case probability is a weighted mean of annual typical use failure rates for nonprescription contraceptive methods (male condoms, withdrawal, fertility awareness–based methods, and spermicides) and no method use, based on the distribution of current use of these methods observed among women veterans at risk for unintended pregnancy in the Examining Contraceptive Use and Unmet Need Among Women Veterans (ECUUN) study.4,6
Indicates the probability that newborn care is paid for by the VA among women whose pregnancy care is covered by the VA.
Indicates the maximum amount of time that can be covered by OCPs if a woman misses at least 7 days between refills in a time horizon of twelve 28-day time periods (336 days).