Figure 5.

Acquisition curves and effects of dHip or mPFC MSCI inactivation on performance in the double-H maze task. Drug-free acquisition expressed as average ± SEM distance swum (a, b) to reach the platform. All rats were subjected to four daily trials on days 1, 2, 4, and 5. On days 3 and 6, they were given a probe trial after bilateral infusion of either 0.26 or 0.70 nmol of MSCI or PBS as control. There was no significant difference among the six groups in terms of overall performance or learning curves. Probe trial performance is expressed as the time spent in the place target arm (i.e., NE arm) in c and d and the time spent in the response arm (N arm) in e and f in rats subjected to infusions into the mPFC or dHip. Representative swim paths are shown in g for each group; all rats were released from SW arm and taken out of the maze at the end of the 60 s probe trial. Abbreviations are as in Figure 4. ^#p < 0.05, significant difference compared with PBS; *p < 0.05, significant difference compared with chance (indicated by the hatched line in c–f).