Figure 7.

Acquisition curves and effects of ReRh MSCI inactivation on spatial memory retrieval in the hidden version of the water-maze task. a, Drug-free acquisition was expressed as average ± SEM distance to reach the platform in the rats that were subsequently tested for a probe trial after MSCI or PBS infusion. All rats were subjected to four daily trials over 8 consecutive days. There were no significant differences between the three groups. Mean ± SEM performance during the probe trial were expressed as percentage time in the target quadrant (b) and the number (± SEM) of crossings in the annulus (c).The dashed line in b represents chance level (i.e., 25%). Abbreviations are as in Figure 4. *p < 0.05, significant difference compared with chance (25%); ^#p < 0.05, significant difference compared with control. d, Examples of detailed swim paths during the probe trial. Patterns are shown for a rat displaying the best performance, i.e., highest percentage of time spent in the target quadrant (top) and for a rat showing performance closest to the mean (bottom).