Figure 4.

TgCRND8 neural progenitors generate an increased number of DCX⁺ neuroblasts and CR⁺ postmitotic neurons in vivo. A, Quantification of DCX-IR cells in SGZ, GCL, and DG of 32-week-old WT and TgCRND8 mice revealed a significantly increased number in the GCL and DG of TgCRND8 mice compared with their WT littermates. B, C, Quantification of DCX⁺/BrdU⁺ cells in 32-week-old WT and TgCRND8 mice killed 24 h (B) and 21 d (C) after BrdU injection. D, Quantitative analysis of CR-IR cells in the SGZ, GCL, and total DG of 32-week-old mice revealed a significantly increased number in all hippocampal subregions TgCRND8 mice compared with WT littermates. A–D, Data represent the mean number ± SD. *p < 0.05, **p < 0.01 versus WT mice (Student's t test).