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. 2013 May 1;33(18):7654–7666. doi: 10.1523/JNEUROSCI.0091-13.2013

Figure 1.

Figure 1.

The effects of prenatal immune activation by 5 mg/kg of polyI:C on anxiety (A), behavioral despair (B), and horizontal (C, D) and vertical activity (E, F) in WT and Disc1-Q31L+/− mice. A, Adult Disc1-Q31L+/− offspring born to mothers injected with 5 mg/kg of polyI:C showed more frequent risk assessment in the EPM task (n = 7–12 per each group) compared with WT mice, with no effect on the duration of floating in the FST (B) (n = 7–17 per each group). Mice of both genotypes born to polyI:C-treated mothers showed a significant deficit in exploration, assessed as vertical activity in the OF (E, F), with mild effect on horizontal activity in WT offspring (C) and no effect on Disc1-Q31L+/− mice (D) (n = 10–17 per each group). *p < 0.05; **p < 0.01 in comparison with control (offspring born to PBS-treated mothers) within each genotype.