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. 2013 May 1;33(18):7654–7666. doi: 10.1523/JNEUROSCI.0091-13.2013

Figure 2.

Figure 2.

The effects of prenatal immune activation on PPI (A), object recognition (B–D), and LI (E) in WT and Disc1-Q31L+/− mice. Adult WT offspring of both genotypes born to mothers injected with 5 mg/kg of polyI:C expressed PPI deficits at 16 weeks but not at 8 weeks of age (A) (n = 8–19 per each group). Adult Disc1-Q31L+/− offspring born to mothers either treated by polyI:C or PBS showed PPI deficits (n = 9–17 per each group). *p < 0.05; **p < 0.01, in comparison with control mice; #p < 0.05, in comparison with WT offspring born to PBS-treated dams. B, Adult mice of all experimental groups showed similar habituation to objects but immune-challenged offspring of both genotypes had spatial object recognition deficits; #p < 0.001, in comparison with the first time interval of the habituation within each experimental group (C). Mice of all experimental groups showed comparable novel object recognition (D). N = 6–12 per each group; **p < 0.01; ***p < 0.001, compared with the time spent on either NDO or FO within each experimental group; #p < 0.01, compared with WT offspring born to PBS-treated dams. E, MIA by 5 mg/kg of polyI:C disrupted LI in both WT and Disc1-Q31L+/− offspring. Mean suppression ratios of the PE and NPE mice conditioned with two conditioned stimulus—unconditioned stimulus trials and given 40 pre-exposures (N = 6–7 per each group). *p < 0.05; ***p < 0.001, in comparison with PE within each experimental group; #p < 0.05, in comparison with PE control mice for each genotype.