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. 2013 May 1;33(18):7654–7666. doi: 10.1523/JNEUROSCI.0091-13.2013

Figure 5.

Figure 5.

The PPI and LI deficits triggered in Disc1-L100P+/− offspring by mild MIA were prevented by coadministration of anti-IL-6 with polyI:C. A, Disc1-L100P+/− offspring born to mothers injected with 2.5 mg/kg of polyI:C had a PPI deficit. Coadministration of anti-IL-6 with polyI:C blocked PPI impairment, with a mild increase of startle response (B). *p < 0.05; **p < 0.01, in comparison with Disc1-L100P+/− offspring born to PBS-treated females. N = 8–9 per group (C). Mean suppression ratios of the PE and NPE mice conditioned with two conditioned stimulus—unconditioned stimulus trials and given 40 pre-exposures (N = 6–9 per each group). **p < 0.01; ***p < 0.001, in comparison with PE within each experimental group.