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The effect of MIA on IL-6 in WT, Disc1-Q31L+/−, and Disc1-L100P+/− fetal brains
| Experimental group | PBS, pg/μg protein | PolyI:C-2.5 mg/kg, pg/μg protein | PolyI:C-5.0 mg/kg, pg/μg protein |
|---|---|---|---|
| WT | 22.5 ± 11.5 | 86.8 ± 25.4* | 168.6 ± 17.7*** |
| Disc1-Q31L+/− | 21.1 ± 5.9 | 93.6 ± 27.1* | 212.1 ± 25.9*** |
| Disc1-L100P+/− | 20.5 ± 6.8 | 315.7 ± 31.5*** | 923.5 ± 30.6*** |
*p < 0.05;
***p < 0.001,- in comparison with control (fetuses of PBS-treated females) within each genotype. N = 8 mice per each group.
