Figure 8.

Suppressive action of WIN on EPSPs at both pathways and occlusion of TBS-induced het-LTD by preceding activation of CB₁R. A, B, CB₁R agonist WIN suppressed both UL-evoked EPSPs (A) and WM-evoked EPSPs (B). WIN was applied to CG cells through the perfusion medium during the period indicated by a horizontal line. White arrows indicate that the intensity of test shocks was increased to the level at which the original size of EPSPs was obtained. Then TBS was applied to the UL site, as indicated by a black arrow in A. Hom-LTP was induced at the UL→L6 synapses (A, filled circles) but het-LTD was not induced at WM→L6 synapses (B, filled circles). Open circles in A and B indicate control data obtained without WIN. The other conventions are the same as in Figure 7A.