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. 2013 May 1;33(18):7710–7727. doi: 10.1523/JNEUROSCI.3021-12.2013

Figure 8.

Figure 8.

Colocalization of nuclear-localized p62 with mutant AR. A–C, 1C2 (red) and anti-HA (green) double immunofluorescence in the spinal cord (A) and skeletal muscle (B) of 16-week-old AR–97Q mice and in the spinal anterior horn cells (C) of SBMA patients. Double-immunofluorescence staining revealed p62 and mutant AR colocalization in NIs (shown in yellow, arrow), but no colocalization was observed in the DNS (arrowhead) in AR–97Q mice and SBMA patients. Scale bars, 20 μm. D, Immunohistochemistry for the anti-p62 antibody in SBMA patients. p62 was localized in the NIs. Scale bar, 10 μm.