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. 2019 Jun 5;12(12):2554–2557. doi: 10.1002/cssc.201900886

Scheme 3.

Scheme 3

Scope of latent nucleophiles in the mechanochemical Reformatsky reaction. Reaction conditions: aldehyde/ketone (1 mmol), ethyl 2‐bromoacetate (1.2 mmol), zinc flake (ca. 325 mesh, 2 equiv), mixer mill, 30 Hz, 2 h. Yields refer to isolated products.