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. 2013 Apr 10;33(15):6540–6551. doi: 10.1523/JNEUROSCI.5087-12.2013

Figure 11.

Figure 11.

IL-1β- and TNF-α-induced hyperalgesia are prevented by glial cell blockade. A, Intrathecal injection of TNF-α (20 ng in 10 μl of saline) induces a significant reduction in the withdrawal latency in response to a radiant heat source compared with baseline levels (n = 9 animals, p < 0.001, two-way RM ANOVA). Intrathecal injection of fluorocitrate (1 nmol in 10 μl of saline) 2 h before TNF-α fully prevents cytokine-induced hyperalgesia (n = 9 animals, p > 0.05, two-way RM ANOVA). B, Spinal injection of IL-1β (20 ng in 10 μl of saline) induces heat hyperalgesia in nine animals tested (p < 0.001, two-way RM ANOVA). Fluorocitrate inhibits IL-1β-induced hyperalgesia significantly (n = 9 animals, p > 0.05, two-way RM ANOVA).