Figure 3.

Depletion of DCX⁺ cells does not alter animals' performance in a range of general nonhippocampal-related tasks. A, B, DT treatment did not affect behavior of experimental mice in the open field test. Similarly, motor performance on the accelerating rotarod (C) and pain sensitivity, as assessed by the hot-plate test (D) (WT: n = 6; DCX^DTR: n = 5), were unaffected. DCX^DTR mice appeared to spend less time in the open arms of an elevated plus maze (EPM) (E), although this was not statistically significant (WT: n = 9; DCX^DTR: n = 11). F, DT administration did not negatively affect the body weight of experimental mice (WT: n = 16; DCX^DTR: n = 16).