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. 2013 Apr 10;33(15):6298–6309. doi: 10.1523/JNEUROSCI.2033-12.2013

Figure 3.

Figure 3.

Huntingtin interacts with dynein and TrkB. A, Coimmunoprecipitation of HTT with TrkB from HEK cells transfected with TrkB and HTTN-1301–17Q or HTTN-1301–73Q show no interaction differences upon polyQ expansion in HTT. B, Immunoprecipitation of TrkB from HEK cells transfected with TrkB and dynein IC-1B or IC-2C reveals a preferential interaction of TrkB with dynein IC-1B compared with dynein IC-2C. C, HEK cells were transfected with TrkB, dynein IC-1B, and HTTN-1301–17Q or HTTN-1301–73Q. Anti-TrkB or dynein antibodies specifically coimmunoprecipitate wild-type and mutant HTT with the same efficacy. D, Trk or dynein immunoprecipitations were performed from Hdh+/+ and HdhQ111/Q111 mouse brain extracts. HD mutation does not affect HTT coimmunoprecipitation.